COMPANY RESEARCHCo-commercializes approved LINZESS and holds regional rights, alongside oral peptide discovery through Nimble. ABBV-859 is in Phase 1; its exact structure and mapping to Nimble assets remain unconfirmed.
Profile review: 2026-11-04 · Fields retain their individual source dates. Undisclosed values are not zero; early or historical events do not establish the latest financing. Awards and acquisitions are distinguished from equity rounds.
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AbbVie completed its acquisition of Nimble in 2025, adding an oral IL23R peptide and synthesis / screening platform. The program was preclinical at the time of that announcement.
Add approved linaclotide commercial roles and a separately labeled ABBV-859 Phase 1 fact; do not infer exact ring structure or asset identity from secondary databases alone.
| Program / service | Target / indication | Representative stage | Evidence & scope |
|---|---|---|---|
| Nimble oral IL23R peptide | IL-23R · Psoriasis | Preclinical（历史） | Quantitative human results not confirmed in this review |
| linaclotide / LINZESS | GC-C · Constipation-related GI indications; subject to local labeling | Approved | Acts locally in the gut; systemic oral bioavailability is not the objective |
Company-name matches are discovery leads; verify entity identity and transaction roles in the original source.
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Johnson & Johnson reported that 58% of patients receiving icotrokinra 200 mg achieved ACR20 at Week 16 in ICONIC-PsA 1, versus 41% with placebo. The oral IL-23 receptor peptide also showed skin responses. The company reported no new safety signals through Week 24; active psoriatic arthritis remains an investigational indication.
Entera reported $265.9 million in cash and cash equivalents at September 30, plus $6.5 million in restricted cash. Its November 6 update targets first site activation for an approximately 900-patient EB613 osteoporosis Phase 3 trial in late 2026. EB613 is an oral PTH(1-34) program, included here as an adjacent oral-peptide delivery development, not a cyclic-peptide candidate.
Johnson & Johnson reported that ICONIC-ASCEND met its Week 16 co-primary endpoints: PASI 90 responses were 55.2% with icotrokinra versus 3.6% with placebo, and IGA 0/1 responses were 70.4% versus 9.5%. At Week 28, the oral peptide met noninferiority criteria versus ustekinumab across multiplicity-controlled key secondary skin-clearance endpoints.
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