COMPANY RESEARCHOriginal Haisco disclosures identify HSK29116 as an oral BTK PROTAC; the NCI Drug Dictionary specifies CRBN recruitment.
Profile review: 2026-11-04 · Fields retain their individual source dates. Undisclosed values are not zero; early or historical events do not establish the latest financing. Awards and acquisitions are distinguished from equity rounds.
Disease tags match recorded text mentions and require program-level verification.
Phase 1 human data and formulation-enhanced PK have been disclosed for HSK47388. A psoriasis Phase 2 registry entry was located, but its dynamic text was not extracted, so Phase 2 is not yet verified.
The January 2026 company release states that psoriasis Phase 2 began in Q4 2025; cyclization is not fully disclosed.
Original Haisco disclosures identify HSK29116 as an oral BTK PROTAC; the NCI Drug Dictionary specifies CRBN recruitment.
HSK40118 previously received clinical authorization, but its continued active advancement cannot be inferred automatically from the latest annual report.
| Program / service | Target / indication | Representative stage | Evidence & scope |
|---|---|---|---|
| HSK47388 | IL-23 pathway · Psoriasis / ulcerative colitis | Phase 2 | Company-disclosed Phase 1 and enhanced-formulation PK; no absolute bioavailability |
| HSK29116 | BTK · See individual trial / indication; not individually confirmed in this review | Phase 1 | IND / clinical entry disclosed; public human results not confirmed in this review |
Company-name matches are discovery leads; verify entity identity and transaction roles in the original source.
No cataloged update explicitly mentions this company.
Johnson & Johnson reported that 58% of patients receiving icotrokinra 200 mg achieved ACR20 at Week 16 in ICONIC-PsA 1, versus 41% with placebo. The oral IL-23 receptor peptide also showed skin responses. The company reported no new safety signals through Week 24; active psoriatic arthritis remains an investigational indication.
Entera reported $265.9 million in cash and cash equivalents at September 30, plus $6.5 million in restricted cash. Its November 6 update targets first site activation for an approximately 900-patient EB613 osteoporosis Phase 3 trial in late 2026. EB613 is an oral PTH(1-34) program, included here as an adjacent oral-peptide delivery development, not a cyclic-peptide candidate.
Johnson & Johnson reported that ICONIC-ASCEND met its Week 16 co-primary endpoints: PASI 90 responses were 55.2% with icotrokinra versus 3.6% with placebo, and IGA 0/1 responses were 70.4% versus 9.5%. At Week 28, the oral peptide met noninferiority criteria versus ustekinumab across multiplicity-controlled key secondary skin-clearance endpoints.
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