COMPANY RESEARCHLIPFENDRA is a U.S.-approved oral PCSK9 inhibitor. Its label confirms sodium caprate and approximately 1% oral bioavailability.
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enlicitide (MK-0616) is a PCSK9 macrocyclic peptide; its 2026 U.S. label supports approved status.
The 20 mg film-coated tablet contains sodium caprate. The label reports approximately 1% oral bioavailability and requires dosing on an empty stomach.
The original CORALreef HeFH study was a 303-patient, 52-week randomized trial; it was not designed to assess cardiovascular outcomes.
2026-05-07: Merck reports biocatalytic manufacturing route for oral macrocycle enlicitide
2026-07-16: FDA approves enlicitide, bringing an oral PCSK9 macrocycle to market
MSD's website records joint clinical development of an MGD candidate with Degron on 2026-05-21. Original MSD / Proxygen announcements describe a multi-target molecular glue collaboration. C4's 2026 SEC filing states that MSD's DAC agreement ended in November 2025.
| Program / service | Target / indication | Representative stage | Evidence & scope |
|---|---|---|---|
| enlicitide / MK-0616 | PCSK9 · Hypercholesterolemia in adults | Approved | Approximately 1% bioavailability (label) |
| Degron / Proxygen molecular glue collaborations; historical C4 DAC collaboration (terminated) | Collaboration targets / named candidates not confirmed in this source · Determined by the collaboration program | Platform / services | This record does not claim platform-wide human validation |
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Johnson & Johnson reported that 58% of patients receiving icotrokinra 200 mg achieved ACR20 at Week 16 in ICONIC-PsA 1, versus 41% with placebo. The oral IL-23 receptor peptide also showed skin responses. The company reported no new safety signals through Week 24; active psoriatic arthritis remains an investigational indication.
Entera reported $265.9 million in cash and cash equivalents at September 30, plus $6.5 million in restricted cash. Its November 6 update targets first site activation for an approximately 900-patient EB613 osteoporosis Phase 3 trial in late 2026. EB613 is an oral PTH(1-34) program, included here as an adjacent oral-peptide delivery development, not a cyclic-peptide candidate.
Johnson & Johnson reported that ICONIC-ASCEND met its Week 16 co-primary endpoints: PASI 90 responses were 55.2% with icotrokinra versus 3.6% with placebo, and IGA 0/1 responses were 70.4% versus 9.5%. At Week 28, the oral peptide met noninferiority criteria versus ustekinumab across multiplicity-controlled key secondary skin-clearance endpoints.
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