COMPANY RESEARCHPL8177 is a colon-delivered cyclic heptapeptide MC1R agonist. The company reported Phase 2 UC proof of concept and explicitly welcomes partnerships / licensing.
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PL8177 is a colon-delivered cyclic heptapeptide MC1R agonist. The company reported Phase 2 UC proof of concept and explicitly welcomes partnerships / licensing.
| Program / service | Target / indication | Representative stage | Evidence & scope |
|---|---|---|---|
| PL8177 | MC1R · Ulcerative colitis | II期结果 | Designed for local activity; high systemic bioavailability is not required |
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Johnson & Johnson reported that 58% of patients receiving icotrokinra 200 mg achieved ACR20 at Week 16 in ICONIC-PsA 1, versus 41% with placebo. The oral IL-23 receptor peptide also showed skin responses. The company reported no new safety signals through Week 24; active psoriatic arthritis remains an investigational indication.
Entera reported $265.9 million in cash and cash equivalents at September 30, plus $6.5 million in restricted cash. Its November 6 update targets first site activation for an approximately 900-patient EB613 osteoporosis Phase 3 trial in late 2026. EB613 is an oral PTH(1-34) program, included here as an adjacent oral-peptide delivery development, not a cyclic-peptide candidate.
Johnson & Johnson reported that ICONIC-ASCEND met its Week 16 co-primary endpoints: PASI 90 responses were 55.2% with icotrokinra versus 3.6% with placebo, and IGA 0/1 responses were 70.4% versus 9.5%. At Week 28, the oral peptide met noninferiority criteria versus ustekinumab across multiplicity-controlled key secondary skin-clearance endpoints.
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