An April 2025 website announcement identifies TQB3019 as the OAPD platform's first oral BTK PROTAC and reports Chinese clinical authorization.
Mainland ChinaFull profile →
Protein degradation / PROTAC · Companies
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Disease tags identify mentions in recorded facts or pipeline text, not approved indications or a complete pipeline. Platform service providers may have no disease-specific tag.
74 matching companiesShowing 49–72 / 74
The official pipeline explicitly lists HJ-002 and HJ-004 as EGFR PROTACs for NSCLC and advanced cancers, respectively.
Mainland ChinaFull profile →
The website lists NanoBRET/TR-FRET/SPR and HiBiT/JESS platforms for permeability, target engagement, ternary complexes, and quantitative degradation kinetics.
United StatesFull profile →
A dedicated page describes E1/E2/E3 and deubiquitinase assays for the ubiquitin–proteasome system, plus PROTAC evaluation from ternary complexes to degradation kinetics and selectivity.
Mainland ChinaFull profile →
CHARMED provides parallel synthesis with common E3 ligands and linkers, degradation screening, and early ADME. The website identifies an SHP2 degrader collaboration with Japan's UBE.
United KingdomFull profile →
An official technical poster describes development of bifunctional degraders using novel E3 ligases and construction of molecular glue libraries.
GermanyFull profile →
The website offers CRBN/VHL/IAP degrader design and synthesis, binary / ternary binding, NanoBRET, HiBiT, ubiquitination, and direct-to-biology workflows, and lists a collaboration with Amphista.
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The company explicitly accepts FFS, cost-sharing, and FTE models. Its dedicated page lists validated assays for BRD4, KRAS, CRBN/VHL binding, and ternary complexes.
United StatesFull profile →
The website explicitly offers PROTAC and molecular glue screening and drug discovery support, describing assay systems for degradation research.
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A dedicated R&D Systems page explicitly offers custom active-degrader design / synthesis, building-block panels, and E3 ligase development, including a Tocris client case.
United StatesFull profile →
On 2026-08-13, FDA granted accelerated approval to iberdomide (Zenbexus) with daratumumab/hyaluronidase-fihj and dexamethasone for certain previously treated multiple myeloma patients. It is a CRBN-modulating CELMoD.
United StatesFull profile →
On 2026-06-08, Roche announced joint development and commercialization with Nurix of the oral BTK degrader bexobrutideg (NX-5948), with CLL Phase 3 planned for summer 2026.
SwitzerlandFull profile →
Kymera's Q2 2026 update reports that Sanofi began first-in-human Phase 1 KT-485 (SAR447971), an oral IRAK4 degrader, in June. Sanofi is responsible for subsequent development, regulatory work, and commercialization.
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DT2216 is a VHL-recruiting BCL-XL PROTAC. An original 2025 Phase 1 paper in 20 patients reports human PK and peripheral leukocyte BCL-XL reduction. NCI lists combination studies in ovarian and fibrolamellar liver cancers.
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An original joint announcement with Photys on 2026-08-13 reports Phase 1 healthy-volunteer dosing of HPB-143/PHT-776. Polymed licensed development and commercialization rights outside Greater China and Southeast Asia to Photys.
Mainland ChinaFull profile →
An original Nurix announcement on 2026-09-29 reports a research milestone in the Pfizer DAC collaboration. Pfizer handles antibody conjugation and subsequent development. Global vepdegestrant development, manufacturing, and commercialization rights transferred to Rigel in June 2026.
United StatesFull profile →
Lilly's website lists LY4584180 as an oral, monovalent BCL6 polymerizing molecular glue. Phase 1 NOVA-BCL6-1, NCT07226843, is recruiting; UCSF's trial page records an April 2026 start.
United StatesFull profile →
A dedicated official page offers PROTAC and partial-PROTAC synthesis, E3 ligand / linker design, molecular glues, ternary-complex and cellular degradation evaluation, and custom ADME/PK and toxicology services, through standalone or integrated projects.
IndiaFull profile →
The official custom synthesis page explicitly lists molecular glue libraries and bifunctional compounds including PROTACs, with FTE quotations and IP-sensitive work under confidentiality agreements.
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Almac Discovery's current official pipeline lists an oral GSPT1 molecular glue and a GSPT1 degrader–antibody conjugate, both preclinical. DAC payloads are used in HER2/CD33-targeted constructs.
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The group website lists TPD as a CRO service. Custom offerings explicitly cover target engagement, modulation, and degradation, plus custom proteins, cell lines, and assay development.
LuxembourgFull profile →
The website explicitly offers PROTAC and molecular glue screening, including HiBiT, proteomics, ternary-complex structures, ADME/DMPK, in vivo formulations, and safety services.
United StatesFull profile →
An official page explicitly offers ligand / linker design, ternary-complex prediction, mechanism / selectivity evaluation, DMPK, early CMC, solubility, crystallization, and formulation strategies.
GermanyFull profile →
The service page covers target / E3 ligand discovery, linker optimization, SPR/ITC, ubiquitination and degradation assays, and custom ADME and PBPK modeling.
PolandFull profile →
Coverage expands from sourced records; this database does not claim all biopharma companies.