Structure of the active pharmaceutical ingredient bismuth subsalicylate
Academic source · Nature Communications
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
Three-dimensional electron diffraction and scanning transmission electron microscopy resolved the layered structure and stacking variations of bismuth subsalicylate, a long-used pharmaceutical ingredient. Clustering compatible diffraction datasets helped obtain the ordered structural model, while imaging exposed disorder. The paper shows why complementary electron-crystallography techniques can be valuable when small crystals and structural defects obstruct conventional characterization.
Why this paper is included
A compelling API case where diffraction and imaging answer different structural questions; disorder should not be reduced to an idealized crystal model.
The interpretation above is analysis, not a conclusion attributed to the original source.
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