Crystal Structures of Two Important Pharmaceuticals Solved by 3D Precession Electron Diffraction Tomography
Academic source · Organic Process Research & Development
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
Researchers determined crystal structures of ramelteon and tolvaptan using three-dimensional precession electron diffraction tomography on approximately 500-nanometer crystals. Structures from subsequently grown, much larger crystals were measured by single-crystal X-ray diffraction for comparison. Agreement in molecular conformation, packing, and unit-cell parameters supported the electron-diffraction workflow for these two pharmaceutical materials.
Why this paper is included
A direct API benchmark against single-crystal X-ray structures provides stronger application evidence than an instrument demonstration alone.
The interpretation above is analysis, not a conclusion attributed to the original source.
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