Direct structure determination of vemurafenib polymorphism from compact spherulites using 3D electron diffraction
Academic source · Communications Chemistry
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
Researchers determined the structures of five vemurafenib polymorphs directly from compact spherulites using 3D electron diffraction. Three matched known single-crystal X-ray structures, while the method resolved a difficult delta form and a newly observed epsilon form. The work expands access to melt-grown polymorphs whose morphology or instability can frustrate conventional single-crystal analysis.
Why this paper is included
Highly relevant to polymorph-screening laboratories because it analyzes the screening product itself instead of requiring suitable isolated single crystals.
The interpretation above is analysis, not a conclusion attributed to the original source.
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