40 years later: completion of the structural characterization of the anxiolytic drug buspirone HCl and solid-form landscape expansion
Academic source · RSC Advances
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
Electron diffraction established the previously unresolved structure of buspirone hydrochloride Form 2. The study also prepared 15 multicomponent solids, including cocrystals, an ionic cocrystal, and salts, and compared conformations and thermal behavior. This expands structural knowledge of a long-marketed drug and provides a solid-form exploration example without demonstrating improved clinical performance for the newly prepared materials.
Why this paper is included
Demonstrates that long-established APIs can still have unresolved polymorph structures, and links electron diffraction to a broader multicomponent solid-form development program.
The interpretation above is analysis, not a conclusion attributed to the original source.
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