Absolute configuration determination of pharmaceutical crystalline powders by MicroED via chiral salt formation
Academic source · Chemical Communications
Source published:
Site published: 2026-11-03 · Updated: 2026-11-03
This source is linked automatically. Choose a question to get started.
What the paper reports
The authors determined the absolute configuration of a preclinical API by forming a salt with a chiral reference and analyzing its microcrystalline powder using MicroED. This approach transfers known stereochemical information from the salt former to the API. It addresses situations where large crystals cannot be obtained, but depends on a suitable, well-characterized chiral reference.
Why this paper is included
A practical stereochemical-assignment route for quantity-limited APIs; the reference-based logic must be distinguished from direct dynamical absolute-structure determination.
The interpretation above is analysis, not a conclusion attributed to the original source.
Read the original source ↗Prepared through Biotech Assistant’s automated research workflow. Editorial standards and corrections