Distinct Conformations of Mirabegron Determined by MicroED
Academic source · Advanced Science
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
MicroED analysis of mirabegron nanocrystals revealed two molecular conformers within the asymmetric unit and a hydrogen-bonded packing arrangement. The authors compared these solid-state conformations with a previously reported receptor-bound model and discussed differences. The two conformers are not, by themselves, evidence of two separate polymorphs; the study concerns molecular conformation within the observed crystal structure.
Why this paper is included
Useful for interpreting API conformation and packing, with an important distinction between conformational diversity inside a crystal and polymorphism.
The interpretation above is analysis, not a conclusion attributed to the original source.
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