Structure Elucidation of Olanzapine Molecular Salts by Combining Mechanochemistry and Micro-Electron Diffraction
Academic source · Crystal Growth & Design
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
The authors combined liquid-assisted grinding with MicroED to characterize olanzapine molecular salts that had resisted suitable single-crystal growth. The approach also identified minor impurity structures within bulk solids. This pharmaceutical example links mechanochemical preparation to structure determination, while showing that crystallinity alone does not guarantee success with conventional single-crystal X-ray analysis.
Why this paper is included
Directly relevant to salt screening and impurity investigations where bulk powders contain structural information that large-crystal growth fails to reveal.
The interpretation above is analysis, not a conclusion attributed to the original source.
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