BIOTECH ASSISTANT / FIELD NOTES

Related oral peptide reference: Ascletis reports preclinical PK data for once-weekly oral peptides

Company / institutional announcement · Ascletis Pharma (company release via PR Newswire)

Source published: 2026-10-20

Site published: 2026-11-03 · Updated: 2026-11-03

Explore this article with AI

This source is linked automatically. Choose a question to get started.

Ask AI ↗

Findings and limitations Industry implications Related developments

What changed

Ascletis reported that ASC36o, an oral amylin receptor agonist tablet, had an approximately seven-day half-life and 6%–8% oral bioavailability in nonhuman primates. The company said a US Phase 1 study was underway, with human PK results expected by year-end 2026. The quantitative findings are preclinical and do not yet establish once-weekly oral dosing in humans.

Why it may matter

Research perspective: Human exposure, variability, and food effects will be key tests of the delivery platform. This is an oral peptide delivery development, rather than a confirmed oral cyclic peptide program.

The interpretation above is analysis, not a conclusion attributed to the original source.

Read the original source ↗

Prepared through Biotech Assistant’s automated research workflow. Editorial standards and corrections

Oral cyclic peptides Formulation Development & Manufacturing

Follow the evidence

No explicit catalog company name was matched. These are companies in the same field, not attributed participants.

Triastek Oralead Pharma Syneron Bio Merck / MSD Johnson & Johnson

Explore field companies →Explore literature →

Related updates

2026-11-07Johnson & Johnson (PR Newswire)

Icotrokinra meets Phase 3 joint-response endpoint in biologic-naive psoriatic arthritis

Johnson & Johnson reported that 58% of patients receiving icotrokinra 200 mg achieved ACR20 at Week 16 in ICONIC-PsA 1, versus 41% with placebo. The oral IL-23 receptor peptide also showed skin responses. The company reported no new safety signals through Week 24; active psoriatic arthritis remains an investigational indication.

Companies mentionedJohnson & Johnson ↗

Oral cyclic peptides Ask AI ↗

2026-11-06Entera Bio investor filing

Adjacent oral-peptide field: Entera reports $265.9 million cash as EB613 Phase 3 preparations continue

Entera reported $265.9 million in cash and cash equivalents at September 30, plus $6.5 million in restricted cash. Its November 6 update targets first site activation for an approximately 900-patient EB613 osteoporosis Phase 3 trial in late 2026. EB613 is an oral PTH(1-34) program, included here as an adjacent oral-peptide delivery development, not a cyclic-peptide candidate.

Oral cyclic peptides Ask AI ↗

2026-11-06Johnson & Johnson

ICONIC-ASCEND reports icotrokinra noninferiority to ustekinumab in plaque psoriasis

Johnson & Johnson reported that ICONIC-ASCEND met its Week 16 co-primary endpoints: PASI 90 responses were 55.2% with icotrokinra versus 3.6% with placebo, and IGA 0/1 responses were 70.4% versus 9.5%. At Week 28, the oral peptide met noninferiority criteria versus ustekinumab across multiplicity-controlled key secondary skin-clearance endpoints.

Companies mentionedJohnson & Johnson ↗

Oral cyclic peptides Ask AI ↗

Continue your research

All company profiles, filters, and comparisons are open. Sign in for private saves and member discussions.

Open full company map ↗