Electron diffraction determines molecular absolute configuration in a pharmaceutical nanocrystal
Academic source · Science
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
A complete structure analysis of a sofosbuvir–L-proline pharmaceutical cocrystal used electron diffraction from a highly beam-sensitive nanocrystal. Collecting data at multiple positions and using improved intensity extraction enabled structure solution. Dynamical diffraction effects then distinguished the absolute structure despite the sample containing light atoms, establishing an important route to stereochemical assignment.
Why this paper is included
This landmark links dynamical refinement to pharmaceutical stereochemistry, while showing why absolute configuration requires more than a routine kinematical structure solution.
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