Indomethacin Polymorph δ Revealed To Be Two Plastically Bendable Crystal Forms by 3D Electron Diffraction: Correcting a 47‐Year‐Old Misunderstanding
Academic source · Angewandte Chemie International Edition
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
Three-dimensional electron diffraction showed that solution-grown and melt-grown materials previously grouped as delta-indomethacin have different crystal structures. The authors retained delta for the solution-grown form and proposed theta for the melt-grown form. Both displayed plastic bending associated with molecular slip. This case demonstrates how structural measurements can resolve longstanding ambiguity in polymorph identity.
Why this paper is included
A key polymorph-identification case: historical labels and similar morphology can conceal distinct structures with different development implications.
The interpretation above is analysis, not a conclusion attributed to the original source.
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