SCXRD, CSP-NMRX and microED in the quest for three elusive polymorphs of meloxicam
Academic source · IUCrJ
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
Three elusive meloxicam polymorphs required different structure-determination approaches. Single-crystal X-ray diffraction solved Form III, combined crystal structure prediction and NMR crystallography solved Form II, and electron diffraction resolved Form V, which contains four independent molecules in the asymmetric unit. The comparison highlights complementary strengths and limitations rather than establishing one universally superior crystallographic method.
Why this paper is included
A useful method-selection study for challenging drug polymorphs, illustrating why MicroED, CSP, solid-state NMR, and X-ray diffraction belong in one toolkit.
The interpretation above is analysis, not a conclusion attributed to the original source.
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