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Enlicitide lowers LDL-C in Phase 3 heterozygous familial hypercholesterolemia study

Company / institutional announcement · Merck

Source published: 2025-11-09

Site published: 2026-11-03 · Updated: 2026-11-03

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What changed

Merck presented Phase 3 CORALreef HeFH results in adults with heterozygous familial hypercholesterolemia receiving background lipid-lowering therapy. Enlicitide reduced LDL-C by 59.4% versus placebo at week 24 and 61.5% at week 52. The overall safety profile was comparable with placebo. The study evaluated lipid changes rather than cardiovascular-event outcomes.

Why it may matter

Extends oral macrocycle evidence to inherited high-risk dyslipidemia while preserving the distinction between lipid endpoints and cardiovascular outcomes.

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Triastek Oralead Pharma Syneron Bio Merck / MSD Johnson & Johnson

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