Structural Analysis of Active Pharmaceutical Ingredients in Tablets Using 3D ED/MicroED
Academic source · Molecular Pharmaceutics
Source published:
Site published: 2026-11-03 · Updated: 2026-11-03
This source is linked automatically. Choose a question to get started.
What the paper reports
The study examined API crystals directly in Allegra, Clarith, and Ibrance tablets using selected-area 3D ED/MicroED. Fexofenadine hydrochloride Form I and clarithromycin Form II retained their polymorphs, while palbociclib Form A showed slight lattice shrinkage. The results demonstrate formulation-level structural analysis and emphasize that a lattice change and a new polymorph are different findings.
Why this paper is included
Direct tablet measurements make this a particularly useful reference for formulation development, manufacturing comparisons, and investigating API form changes in finished products.
The interpretation above is analysis, not a conclusion attributed to the original source.
Read the original source ↗Prepared through Biotech Assistant’s automated research workflow. Editorial standards and corrections
MicroED structure determination Pharmaceutical solid state Formulation Development & Manufacturing