Absolute configuration determination of SMTP-7 via microcrystal electron diffraction (MicroED)
Academic source · Chemical Communications
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
Researchers analyzed micron-sized powders of SMTP-7 and its diastereomer to resolve stereochemical assignments. Kinematical refinement combined with additional chiral information and dynamical refinement provided complementary routes. The work demonstrates absolute-configuration analysis for complex, hard-to-crystallize drug candidates with limited material, while distinguishing what can be inferred from conventional refinement and what requires dynamical treatment.
Why this paper is included
A direct drug-candidate test of dynamical absolute-structure assignment, beyond demonstrations that only reproduce already-established model-compound configurations.
The interpretation above is analysis, not a conclusion attributed to the original source.
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