Discovery of Oxyacanthine Dihydrochloride Monohydrate Polymorphs from Obfuscated Samples by Microcrystal Electron Diffraction
Academic source · ChemMedChem
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
MicroED identified two polymorphic structures of oxyacanthine dihydrochloride monohydrate in samples mislabeled as berbamine dihydrochloride. The forms differed principally in the conformation of a tetrahydroisoquinoline ring. Structural, energetic, and packing analyses suggested a thermodynamic preference between them. The study demonstrates how crystallographic analysis can expose both identity problems and polymorphism in complex natural-product samples.
Why this paper is included
A relevant identity-and-polymorph case for natural-product materials, emphasizing that resolving a crystal structure can reveal mislabeled inputs as well as solid-form differences.
The interpretation above is analysis, not a conclusion attributed to the original source.
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