Combination of Microcrystal Electron Diffraction and Solid-State NMR for the Structural Determination of Indomethacin–Nicotinamide Co-crystals
Academic source · Chemical and Pharmaceutical Bulletin
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
This study characterized indomethacin–nicotinamide cocrystals using MicroED together with solid-state NMR, Raman spectroscopy, and powder X-ray diffraction. MicroED supplied the crystal structure, while NMR helped examine molecular interactions. The combined approach addressed properties that individual methods could not establish alone, offering a pharmaceutical cocrystal workflow relevant to API powders and formulations containing excipients.
Why this paper is included
A concrete cocrystal example showing how electron diffraction and spectroscopic evidence can complement each other in pharmaceutical structural characterization.
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