Room Temperature Structures of Solvated Organic Molecules Enabled by Liquid Cell Electron Diffraction
Academic source · ACS Central Science
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
Liquid cells made from paired carbon grids retained a thin solution layer around microcrystals for room-temperature MicroED. The study obtained atomic structures from solvated organic molecules and pharmaceutical hydrates while using low-dose, rapid, multi-crystal acquisition to limit beam damage. It extends access to hydrated or solvated states, but sample-specific radiation sensitivity and preparation remain important constraints.
Why this paper is included
Addresses a central pharmaceutical concern: vacuum and drying can alter solvated crystal states, so room-temperature liquid-cell measurements may reveal otherwise inaccessible forms.
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