Predicting the ritonavir crisis by revisiting the polymorph landscape with crystal structure prediction and form 4 structure solution
Academic source · Communications Chemistry
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
Revisiting ritonavir’s polymorph landscape, the authors examined whether crystal structure prediction could have flagged the risk posed by the less soluble Form 2. They also solved the previously unresolved Form 4 structure using 3D electron diffraction, modeling, and powder X-ray diffraction, finding disorder and thermodynamic instability. The retrospective analysis informs risk assessment rather than guaranteeing future polymorph prediction.
Why this paper is included
Connects a classic pharmaceutical polymorphism failure with modern structure determination and computational risk assessment, making the technical implications especially accessible.
The interpretation above is analysis, not a conclusion attributed to the original source.
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