A dedicated page describes E1/E2/E3 and deubiquitinase assays for the ubiquitin–proteasome system, plus PROTAC evaluation from ternary complexes to degradation kinetics and selectivity.
Profile review: 2026-11-04 · Fields retain their individual source dates. Undisclosed values are not zero; early or historical events do not establish the latest financing. Awards and acquisitions are distinguished from equity rounds.
Public financial snapshot
Amounts retain their original currency and units. Consolidated group revenue is not standalone CRO/CDMO service revenue. Year-to-date periods are not standalone quarters.
Period
Currency / basis
Revenue
Net profit
Operating cash flow
Report
FY2025 2025-12-31
CNY PRC Accounting Standards / consolidated
1,134,719,476.3
13,412,160.63 Net income attributable to shareholders of the listed company
Consolidated group financials; not standalone CRO/CDMO segment revenue.
Source unit: CNY.
Earnings include a loss or a negative prior-period base. Any source-reported year-over-year percentage retains the source definition and is not interpreted as conventional positive earnings growth.
2026Q3 (YTD) · Reporting notes
The latest report covers January–September 2026 year to date, not the third quarter alone; unaudited quarterly report.
Consolidated group financials; not standalone CRO/CDMO segment revenue.
Source unit: CNY.
Earnings include a loss or a negative prior-period base. Any source-reported year-over-year percentage retains the source definition and is not interpreted as conventional positive earnings growth.
Disease tags match recorded text mentions and require program-level verification.
Technology, programs & evidence
A dedicated page describes E1/E2/E3 and deubiquitinase assays for the ubiquitin–proteasome system, plus PROTAC evaluation from ternary complexes to degradation kinetics and selectivity.
Program / service
Target / indication
Representative stage
Evidence & scope
UPS enzymology, ternary complexes, ubiquitination, and degradation characterization
Program-dependent / not disclosed · Determined by the collaboration program
Platform / services
This record does not claim platform-wide human validation
Related news & literature
Company-name matches are discovery leads; verify entity identity and transaction roles in the original source.
No cataloged update explicitly mentions this company.
A Nature Materials study describes mRNA-loaded LNPs that reprogram tumor-associated macrophages into Claudin18.2-targeting CAR macrophages. The lipid formulation also promotes TREM2 internalization and degradation, reshaping immune responses. The original abstract reports tumor suppression and longer survival with PD-1 blockade in mice, plus ex vivo patient-sample findings. These findings do not demonstrate clinical efficacy in treated patients.
A Frontiers in Pharmacology review compares direct MCL-1 inhibition with approaches that reduce its abundance, including transcriptional interventions and targeted degradation. The original abstract highlights limited single-agent activity and cardiac safety concerns with inhibitors, while positioning degradation as an unvalidated clinical strategy. Biomarker-guided combinations and dynamic BH3 profiling are discussed; this review does not report a new clinical trial.
Evommune licensed EVO570, formerly HC118, from Hinova for development and commercialization outside Greater China. Upfront consideration totals $30 million: $20 million cash and $10 million in pre-funded warrants. Additional development, regulatory, and commercial milestones could reach approximately $1.1 billion, plus royalties. Phase 1 was expected to begin shortly; the announcement does not establish human efficacy.
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