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MRNA / LNP / RESEARCH LIBRARY
Important mRNA/LNP publications from the past 120 days
Search bilingual publication guides on delivery, in vivo CAR-T, therapeutic translation, safety, analytics, and manufacturing.
A Nature Materials study describes mRNA-loaded LNPs that reprogram tumor-associated macrophages into Claudin18.2-targeting CAR macrophages. The lipid formulation also promotes TREM2 internalization and degradation, reshaping immune responses. The original abstract reports tumor suppression and longer survival with PD-1 blockade in mice, plus ex vivo patient-sample findings. These findings do not demonstrate clinical efficacy in treated patients.
Moderna reported third-quarter 2026 revenue of $1.3 billion, up 29% year over year, and GAAP net income of $162 million, compared with a $200 million loss a year earlier. It raised expected full-year revenue growth to 15%–25% from up to 10%. The company attributed quarterly growth mainly to international COVID vaccine sales supported by government partnerships.
Moderna announced Canadian authorization of mFLUSIVA, its mRNA influenza vaccine, and mCOFLU, its combined influenza and COVID-19 vaccine, for adults 50 and older. The November 5 announcement cites Phase 3 efficacy evidence for mFLUSIVA and immunogenicity comparisons for mCOFLU. The company said it would engage Canadian authorities and immunization partners on future availability.
Ethris reported topline results from a randomized Phase 2a rhinovirus-challenge study involving 50 adults with asthma. A single nasal dose of ETH47, an interferon-lambda-encoding mRNA candidate, produced local expression and lower day-two viral load. Symptom improvements were described as numerical trends; exposure-response subgroup findings remain exploratory, without established clinical efficacy.
Maravai reported third-quarter 2026 revenue of $45.9 million, up 10.1% year over year, with a $24.0 million net loss and $5.8 million in adjusted EBITDA, a non-GAAP measure. The company said mRNA product revenue grew 28% and four discovery-stage mRNA customers moved to clinical-stage GMP. These figures describe company performance, not total RNA-market growth.
Emvena Therapeutics launched with investment from the Penn-BioNTech Innovative Therapeutics Seed Fund to develop placenta-targeted mRNA medicines. Its lead focus is preeclampsia. The announcement describes LNP delivery of VEGF-encoding mRNA and improvements in blood pressure and placental or fetal measures in mouse studies. It does not report human trial results or disclose an investment amount.
Moderna reported initial Phase 1/2 MyEngage findings for mRNA-2808, which encodes three T-cell engagers. Four confirmed responses occurred among 11 response-evaluable patients. Twelve patients had received treatment; Grade 3 or higher treatment-related adverse events occurred in 41.7%. These small, uncontrolled findings are preliminary and do not establish comparative benefit.
IDT and Aldevron launched PE Ultra prime-editor mRNA, chemically modified pegRNAs, and six ABE8e-based editor mRNAs with a parallel screening kit. The companies also described guide-design support and stocked quantities from 20 micrograms to 1 milligram. These are research-use products; the announcement does not establish clinical safety, efficacy, or approval.
Tessera announced three preclinical presentations for the December 2026 ASH meeting. Topics include targeted LNP delivery for functional CAR-T generation in nonhuman primates and in vivo hematopoietic stem-cell editing for sickle cell disease. This is a company announcement of upcoming presentations, not a peer-reviewed publication or evidence of clinical benefit.
Labcorp published a conference-poster summary on independent RNA and DNA integrity assessment in cell and gene therapy bioanalysis. It evaluates Agilent TapeStation microfluidic electrophoresis as an orthogonal quality-control tool alongside qPCR and RT-qPCR, which do not directly measure overall integrity. The public summary describes the evaluation's objective and rationale, without quantitative performance results or peer-reviewed publication metadata.
In a company-issued release carried by BioSpace, Strand announced SITC presentations on intratumoral STX-001 and systemic STX-003, both self-replicating mRNA approaches expressing IL-12. The presentations cover updated STX-001 clinical findings and ASCENT-1 trial design for STX-003. The release does not provide numerical response rates or establish efficacy for systemic administration.
Researchers used the properties of more than 100 central nervous system drugs to design brain-directed ionizable lipids. HX1 nanoparticles delivered RNA and enabled gene editing in mouse brains, delivered reporter mRNA in a nonhuman primate, and reduced radiation-related brain injury in mice carrying Il10 mRNA. These are preclinical findings.
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