Orna develops circular RNA in vivo cell therapies, including CD19-directed ORN-252 for B-cell-driven autoimmune diseases. Lilly completed the acquisition in 2026; its Q3 filing identifies ORN-252 as Phase 1 at acquisition. ReNAgade was acquired by Orna in 2024 and is not counted separately.
Profile review: 2026-11-04 · Fields retain their individual source dates. Undisclosed values are not zero; early or historical events do not establish the latest financing. Awards and acquisitions are distinguished from equity rounds.
Disease tags match recorded text mentions and require program-level verification.
Technology, programs & evidence
Develops circular RNA (oRNA) and LNP delivery. Its current LinkedIn page identifies it as a wholly owned Eli Lilly subsidiary, so it should not be treated as an independent private platform company.
Orna develops circular RNA in vivo cell therapies, including CD19-directed ORN-252 for B-cell-driven autoimmune diseases. Lilly completed the acquisition in 2026; its Q3 filing identifies ORN-252 as Phase 1 at acquisition. ReNAgade was acquired by Orna in 2024 and is not counted separately.
Program / service
Target / indication
Representative stage
Evidence & scope
RNA / delivery technology platform
Project-dependent / not verified · Project-dependent / not verified
Not verified
This record does not establish human validation of the entire platform
ORN-252
CD19 · See program source; distinguish indications
Phase 1
Human research disclosed or registered; efficacy is not established.
Related news & literature
Company-name matches are discovery leads; verify entity identity and transaction roles in the original source.
No cataloged update explicitly mentions this company.
A Nature Materials study describes mRNA-loaded LNPs that reprogram tumor-associated macrophages into Claudin18.2-targeting CAR macrophages. The lipid formulation also promotes TREM2 internalization and degradation, reshaping immune responses. The original abstract reports tumor suppression and longer survival with PD-1 blockade in mice, plus ex vivo patient-sample findings. These findings do not demonstrate clinical efficacy in treated patients.
CSPC announced initiation of the first Chinese center for SYS6055-003, a Phase 1/2 trial in relapsed or refractory B-cell non-Hodgkin lymphoma. SYS6055 uses lentiviral vectors to generate CD19-targeting CAR-T cells in vivo. The company said recruitment and screening are underway following October clinical-trial authorization. Center initiation does not establish patient dosing, efficacy, or marketing approval.
Azalea reported SITC preclinical findings for its dual-vector in vivo CAR-T platform, combining targeted CRISPR-Cas9 delivery with AAV-mediated CAR insertion at the TRAC locus. The company described leukemia clearance and protection after tumor rechallenge in selected mouse groups, plus dual-antigen and armored designs. These are animal findings, not evidence of efficacy or safety in patients.
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