Lipid Nanoparticle Surface Engineering with Heparosan Polysaccharides Enhances mRNA Efficacy via Reduced Endosomal Retention
Academic source · ACS nano
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
Heparosan surface modification was compared with conventional PEG-based nanoparticles across several ionizable lipid formulations. Modified particles improved expression in immune-cell models and showed reduced association with late endosomes and lysosomes. Mouse experiments assessed repeated expression and vaccine antibody responses. The findings support an alternative surface-engineering approach, while long-term immunogenicity, biodistribution, and manufacturing consistency require additional study.
Why this paper is included
Expands surface-engineering options for immune delivery; trafficking correlations and short-term mouse tolerability do not establish long-term human safety or universal PEG replacement.
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