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Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

Academic source · Nature Nanotechnology

Source published: 2020-04-06 · Event / reporting date: 2020-04-06

Site published: 2026-11-07 · Updated: 2026-11-07

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Findings and limitations Industry implications Related developments

What the paper reports

This 2020 study added a SORT component to lipid nanoparticles to alter tissue targeting and deliver mRNA or CRISPR cargoes. It provides preclinical evidence for extrahepatic delivery, rather than proof of human tissue targeting or clinical benefit.

Why this paper is included

Foundational formulation context for organ-selective delivery; historical backfill.

The interpretation above is analysis, not a conclusion attributed to the original source.

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Prepared through Biotech Assistant’s automated research workflow. Editorial standards and corrections

mRNA / LNP In Vivo Cell Engineering & Gene Editing

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