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Bispecific protein drives dual receptor degradation in mouse eye-disease models

Academic source · Proceedings of the National Academy of Sciences / PubMed

Source published: 2026-11-04 · Event / reporting date: 2026-11-04

Site published: 2026-11-06 · Updated: 2026-11-06

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Findings and limitations Industry implications Related developments

What the paper reports

A PNAS study reports RHV, a tetravalent bispecific protein designed to internalize and lysosomally degrade VCAM-1 and VEGFR on pathological vessels. The original abstract describes activity in mouse choroidal neovascularization models, including efficacy comparable to aflibercept at one-quarter of the molar dose. This is preclinical extracellular receptor degradation, distinct from an intracellular small-molecule PROTAC.

Why this paper is included

Analysis: The findings may broaden targeted degradation strategies for ocular disease, but comparative durability and safety still need validation beyond animal models.

The interpretation above is analysis, not a conclusion attributed to the original source.

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Protein degradation / PROTAC

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No explicit catalog company name was matched. These are companies in the same field, not attributed participants.

Merck / MSD Haisco Pharmaceutical Gilead Sciences Novartis WuXi AppTec / WuXi TIDES

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