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Novartis starts a second Phase 2 trial of VAV1 degrader MRT-6160

Company / institutional announcement · Monte Rosa Therapeutics

Source published: 2026-10-28

Site published: 2026-11-03 · Updated: 2026-11-03

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What changed

Monte Rosa announced that Novartis initiated a second Phase 2 study of the VAV1 molecular glue degrader MRT-6160, also called DDY391, in active moderate to severe psoriatic arthritis. The randomized, double-blind, placebo-controlled trial will assess efficacy, safety, tolerability, and dose response. The first patient visit triggers a $37.5 million milestone payment.

Why it may matter

The trial broadens disease-level testing of VAV1 degradation and could help determine whether deep target depletion translates into useful autoimmune efficacy.

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