Uncovering the influence of lyoprotection on stability of mRNA-LNPs after lyophilization and high temperature storage
Academic source · Journal of Controlled Release
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
Researchers compared 12 lyophilized mRNA-LNP formulations containing sucrose, trehalose, and polyvinylpyrrolidone. A ternary protectant system at a 1:20 lipid-to-protectant ratio preserved particle properties, RNA integrity, and in vitro transfection after one month at 40°C. Sucrose crystallization reduced protection. The results show why physical measurements need functional confirmation and do not establish a clinical product shelf life.
Why this paper is included
Links protectant physical state with functional stability; formulation developers should combine particle and RNA measurements with potency under relevant storage conditions.
The interpretation above is analysis, not a conclusion attributed to the original source.
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