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Nurix enrolls first patient in bexobrutideg–venetoclax combination study

Company / institutional announcement · Nurix Therapeutics

Source published: 2026-10-07 · Event / reporting date: 2026-10-06

Site published: 2026-11-03 · Updated: 2026-11-03

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What changed

Nurix announced the first patient enrollment in NX-5948-203, a Phase 1b/2 trial combining the investigational BTK degrader bexobrutideg with venetoclax in chronic lymphocytic leukemia. Initial enrollment focuses on relapsed or refractory disease. Conducted under the Roche collaboration, the study will assess safety, tolerability, and clinical activity to inform potential combination development across treatment settings.

Why it may matter

Combination testing could clarify how BTK degradation fits existing CLL regimens, but deeper responses and fixed-duration benefits remain hypotheses for evaluation.

The interpretation above is analysis, not a conclusion attributed to the original source.

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