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MAGEA11 recruitment enables selective BET degradation in cancer cell models

Academic source · npj Drug Discovery

Source published: 2026-10-26

Site published: 2026-11-03 · Updated: 2026-11-03

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Findings and limitations Industry implications Related developments

What changed

Researchers developed BET-targeting PROTACs that recruit the tissue-restricted scaffolding protein MAGEA11 rather than relying on widely expressed ligases. Lead compound 105B degraded BET proteins in two cancer cell lines but not in HEK293T cells. Mechanistic experiments implicated MAGEA11 and HUWE1. The authors emphasized that further optimization is needed to produce selective cytotoxicity.

Why it may matter

Tissue-restricted recruitment may offer another route to selectivity, although cellular degradation results do not yet establish an effective therapeutic window.

The interpretation above is analysis, not a conclusion attributed to the original source.

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Protein degradation / PROTAC

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