Enhancing Lipid Nanoparticle-Mediated Circular RNA and mRNA Expression in the Placenta through Inhibition of IFNAR-JAK-STAT Signaling
Academic source · Nano Letters
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
Placenta-tropic LNPs produced strong circular-RNA expression in cultured trophoblasts but weaker translation in pregnant mice than linear mRNA. Researchers identified innate immune signaling as a constraint and increased placental expression by inhibiting IFNAR-JAK-STAT pathways. VEGF-encoding cargos provided a therapeutic-payload demonstration. Immune suppression during pregnancy raises separate safety questions that expression improvements alone cannot resolve.
Why this paper is included
Explains an important in vitro–in vivo translation gap; pregnancy applications require rigorous maternal, fetal, and immunological safety assessment.
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