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C4 Therapeutics expands target-first DEL capabilities for molecular glue discovery

Company / institutional announcement · C4 Therapeutics

Source published: 2026-10-29 · Event / reporting date: 2026-10-29

Site published: 2026-11-03 · Updated: 2026-11-03

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Findings and limitations Industry implications Related developments

What changed

C4 Therapeutics described a DNA-encoded library that incorporates its cereblon-binding ligand collection for target-first molecular glue discovery. The company reported known and novel VAV1 degrader hits as platform validation, while stating that it would not advance VAV1 without a partner. This is a discovery-platform update, not the clinical entry of a new drug candidate.

Why it may matter

Research perspective: Target-first molecular glue screening may create new discovery-partnership opportunities. Hits still require validation of selectivity, degradation mechanism, developability, and translational relevance.

The interpretation above is analysis, not a conclusion attributed to the original source.

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