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RESEARCH / LITERATURE

Research Literature

Find research, methods, and reviews across our scientific fields.

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Bioanalysis & Biomarkers 4

Duplicate DOIs are merged. This is a selected collection, not an exhaustive bibliography.

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Methods
Bioanalysis

Multiplex assay separates domain-specific ADA responses using a PEGylated Cas9 model

Jason Truesdale; Michael Mulvana; Stephen Lowes; Christopher Dishinger

A Bioanalysis paper describes development and prevalidation of a Luminex xMAP assay for simultaneous domain-specific anti-drug antibody detection. Using PEGylated Cas9 as a model, the authors report adjustable bead ratios and on-demand coupling to accommodate different minimum required dilutions. The original abstract supports assay feasibility, rather than universal validation across multidomain therapeutics or demonstrated clinical benefit.

Bioanalysis & Biomarkers
Read guide →Original paper ↗

DOI: 10.1080/17576180.2026.2753978

Reviews & perspectives
Bioanalysis

Review explains statistical pitfalls in anti-drug antibody assay cut points

Brijesh Kumar Verma

Based on the PubMed abstract, this review explains how sample selection, experimental balance, outlier handling, transformation, and statistical methods affect anti-drug antibody assay cut points. It addresses screening, confirmation, titers, drug tolerance, and reassessment using clinical baseline samples. This is a practical review of validation decisions, not a new clinical efficacy study.

Bioanalysis & Biomarkers
Read guide →Original paper ↗

DOI: 10.1080/17576180.2026.2758542

Reviews & perspectives
Bioanalysis

Review examines greener solvent systems for bioanalytical microextraction

Styliani Nisyriou; Marianna Ntorkou; Christina Patakidou; Constantinos K Zacharis

Based on the PubMed abstract, a Bioanalysis review examines switchable-hydrophilicity solvents and bio-derived deep eutectic solvents for sample preparation. It discusses extraction performance, matrix effects, reproducibility, and environmental trade-offs, with future emphasis on miniaturization and automation. The review evaluates methodological opportunities rather than validating a specific assay for regulated clinical sample analysis.

Bioanalysis & Biomarkers
Read guide →Original paper ↗

DOI: 10.1080/17576180.2026.2758030

Reviews & perspectives
Nature

Mass-spectrometry-based proteomics: from single cells to clinical applications

Tiannan Guo; Judith A Steen; Matthias Mann

This review surveys improvements in proteomics sample preparation, instrumentation, data acquisition, and analysis. It connects single-cell and spatial profiling with protein interactions, modifications, and biomarker discovery in body fluids. Clinical implementation is discussed as an opportunity with remaining challenges, rather than proof that every discovery assay is ready for diagnostic use.

Bioanalysis & Biomarkers
Read guide →Original paper ↗

DOI: 10.1038/s41586-025-08584-0

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