Communications Chemistry
Direct-infusion method accelerates antibody peptide mapping in a peer-reviewed study
Austin Z. Salome; Marcel Morgenstern; Alexander S. Hebert; Craig D. Wenger; Pavel Sinitcyn; Benton J. Anderson; John S. Chlystek; Lia R. Serrano; Keaton L. Mertz; Ian J. Miller; Erik Miller-Galow; Malika P. Godamudunage; Michael Batt; Bhavin R. Patel; Gihoon Lee; Lloyd M. Smith; Scott T. Quarmby; Alayna M. George Thompson; Joomi Ahn; Harsha P. Gunawardena; Joshua J. Coon
《Communications Chemistry》研究报道RaPiD-mAb-MS，将微孔板制样与直接进样质谱结合进行抗体肽图分析。原始摘要称，约1.5—2小时可分析96个样品，常规序列覆盖率超过95%，应用涉及28种抗体、2,000余份样品；比较涵盖多种修饰与序列变异，更广泛的方法适用性仍需评估。
DOI: 10.1038/s42004-026-02260-8
